Call for a Post-Doctoral Position for a joint post-doc (Champalimaud Neuroscience Programme / Johns Hopkins) for studying windows of plasticity upon ischemia
A fully-funded post-doc position is available now for investigating neuroplasticity in animal models of ischemia. The research is a joint effort between the Neuroplasticity & Neural Activity MRI-Lab at the Champalimaud Neuroscience Programme (CNP) in Lisbon, Portugal (led by Noam Shemesh), the Post-Stroke Plasticity and Motor Learning lab (led by Steven Zeiler), and the Brain, Learning, Animation and Movement (BLAM) Lab (led by John Krakauer) at Johns Hopkins. We seek to understand the neural plasticity underlying motor recovery after stroke, and moreover, to elucidate the processes contributing to short time-window of enhanced plasticity early after stroke. Building on the novel prehension task developed at Johns Hopkins, showing that these effects clearly involve widespread brain regions, we will study these questions using a unique combination of ultrahigh field MRI (facilitating the longitudinal nature of the investigation) and methodologies specialized for detecting subtle microstructural features, as well as optogenetic targeting of suspect circuits within the magnet.
A successful Applicant will have a PhD or MD/PhD (or will be very close to submitting her/his thesis) in Neuroscience/Neurobiology. An excellent, well-documented track-record is imperative. Knowledge of Magnetic Resonance is a plus.
- Cover Letter stating your interests
- A full CV, including list of publications
- Names and email addresses of at least 3 references.
Successful applicants will receive full funding and a private/national health insurance.
The Shemesh Lab in Champalimaud Neuroscience Programme (CNP) investigates neural activity, neuroplasticity, and how they elicit behavioral changes in vivo. These questions are interrogated in the context of normal processes (development, learning…), as well as in neuropsychiatric and neurodegeneration animal models of disease. Our approach involves a plethora of advanced methods, mainly revolving around state-of-the-art preclinical MRI/MRS, augmented by simultaneous ancillary techniques (optogenetics, calcium recordings, advanced behavioral testing). One of the main goals in the Lab is to develop nonBOLD fMRI methods, which will report on neural activity much more directly compared to conventional fMRI.
This ERC-funded Lab benefits from a cutting-edge, ultrahigh field 16.4T scanner, as well as a 9.4T scanner equipped with two 4-element array cryoprobes (for mice and rats, respectively), another 1T scanner for basic scanning and testing in more clinical settings, and lasers for optogenetics / calcium recordings; the Lab also has a fully equipped surgery room, ample space for performing extensive behavioural studies and access to one of Europe’s largest vivaria, including its numerous transgenic lines, neurodegeneration/psychiatric animal models of disease, and ancillary platforms for histology, microscopy, transgenics and viruses, among others.
CNP is situated within the Champalimaud Centre for the Unknown, a private, non-profit foundation residing on Lisbon’s waterfront, right where the River Tejo meets the Atlantic Ocean. CCU provides a stunning and productive working environment, harboring a Neuroscience department for basic research, and a clinical centre for treating cancer patients with pioneering methods. This unique blend of basic research and clinical practice under the same roof, which actively encourages collaborations and exchange of ideas, results in a highly interdisciplinary and stimulating atmosphere. Post-Doctoral salaries are very competitive vis-à-vis Lisbon costs of living, and post-docs further benefit from health insurance.